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Cot inhibitor-2

Name: Cot inhibitor-2
Brand: TargetMol
SKU: T10866
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10866Cas No. 915363-56-3

Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM.

Cot inhibitor-2

🥰Excellent

Purity: 98.87%

Catalog No. T10866Cas No. 915363-56-3

Pack Size	Price	Availability
1 mg	$66	In Stock
5 mg	$160	In Stock
10 mg	$255	In Stock
25 mg	$538	In Stock
50 mg	$793	In Stock
100 mg	$1,130	In Stock
200 mg	$1,520	In Stock
1 mL x 10 mM (in DMSO)	$190	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.87%

Resource Download

COA HPLC HNMR FNMR

Product Introduction

Bioactivity

Description	Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM.
Targets&IC50	TNF-α production (human whole blood):0.3 μM, Cot (Tpl2/MAP3K8):1.6 nM
In vivo	Cot inhibitor-2 (100 mg/kg ; orally ; rats) showed a Cmax of 517 ng/mL (0.89 μM) and AUC of 4841 ng•h/mL.[1] Cot inhibitor-2 (25 mg/kg ; p.o. ; rats) is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats that Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83%.[1]

Chemical Properties

Molecular Weight	539.43
Formula	C₂₆H₂₅Cl₂FN₈
Cas No.	915363-56-3
Smiles	CCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Relative Density.	1.45

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (74.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (4.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8538 mL	9.2690 mL	18.5381 mL	92.6904 mL
5 mM	0.3708 mL	1.8538 mL	3.7076 mL	18.5381 mL
10 mM	0.1854 mL	0.9269 mL	1.8538 mL	9.2690 mL
20 mM	0.0927 mL	0.4635 mL	0.9269 mL	4.6345 mL
50 mM	0.0371 mL	0.1854 mL	0.3708 mL	1.8538 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc